Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh,
Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, and Xu Wu
Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8þ T Cells
Deepak Mittal1,2, Franco Caramia3, Stefan Michiels4,5, Heikki Joensuu6,
Pirkko-Liisa Kellokumpu-Lehtinen7, Christos Sotiriou8, Sherene Loi3, and
Mark J. Smyth1,2
Cell
Volume 164, Issues 1–2, 14 January 2016, Pages 293–309
Resource
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
Highlights
• We screened 77 breast cancer lines using a genome-wide pooled shRNA library
• We developed an algorithm (siMEM) to improve identification of context-dependent genes
• Integrating screen results with genomic data reveals potential “drivers”
• BRD4 is essential for luminal cancer, and mutant PIK3CA confers BET-I resistance
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High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew, Shengdar Q. Tsai, Nhu T. Nguyen, Zongli Zheng & J. Keith Joung
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature16526.html
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Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh,
Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, and Xu Wu
http://www.cell.com/cell-reports/fulltext/S2211-1247(14)00819-5
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Imaging, Biodistribution, and Dosimetry of Radionuclide-Labeled PD-L1 Antibody in an
Immunocompetent Mouse Model of Breast Cancer
http://cancerres.aacrjournals.org.libproxy.helsinki.fi/content/76/2/472.full.pdf+html
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Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8þ T Cells
Deepak Mittal1,2, Franco Caramia3, Stefan Michiels4,5, Heikki Joensuu6,
Pirkko-Liisa Kellokumpu-Lehtinen7, Christos Sotiriou8, Sherene Loi3, and
Mark J. Smyth1,2
http://cancerres.aacrjournals.org/content/76/2/264.long
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Cell
Volume 164, Issues 1–2, 14 January 2016, Pages 293–309
Resource
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
http://www.sciencedirect.com/science/article/pii/S0092867415016244
Highlights
• We screened 77 breast cancer lines using a genome-wide pooled shRNA library
• We developed an algorithm (siMEM) to improve identification of context-dependent genes
• Integrating screen results with genomic data reveals potential “drivers”
• BRD4 is essential for luminal cancer, and mutant PIK3CA confers BET-I resistance
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Click to access S0092-8674%2815%2901624-4.pdf
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CancerCellDisseminationandHomingtotheBone Marrow in a Zebrafish Model Antonio Sacco1, Aldo M. Roccaro1,2, Dongdong Ma3, Jiantao Shi1,Yuji Mishima1, Michele Moschetta1, Marco Chiarini1,2, Nikhil Munshi1, Robert I. Handin2, and Irene M. Ghobrial1
http://cancerres.aacrjournals.org/content/early/2016/01/07/0008-5472.CAN-15-1926.abstract
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FOXO1 couples metabolic activity and growth state in the vascular endothelium
http://www.nature.com/nature/journal/v529/n7585/full/nature16498.html
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