8 thoughts on “JC 20.1.16: General”

  1. Cell
    Volume 164, Issues 1–2, 14 January 2016, Pages 293–309
    Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance


    • We screened 77 breast cancer lines using a genome-wide pooled shRNA library
    • We developed an algorithm (siMEM) to improve identification of context-dependent genes
    • Integrating screen results with genomic data reveals potential “drivers”
    • BRD4 is essential for luminal cancer, and mutant PIK3CA confers BET-I resistance


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