9 thoughts on “JC 3.2.2016: General”

  1. TOPI

    NATURE CELL BIOLOGY | ARTICLE

    Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

    Massiullah Shafaq-Zadah, Carina S. Gomes-Santos, Sabine Bardin, Paolo Maiuri, Mathieu Maurin, Julian Iranzo, Alexis Gautreau, Christophe Lamaze, Patrick Caswell, Bruno Goud & Ludger Johannes

    Click to access ncb3287.pdf

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  2. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

    Alice Soragni, Deanna M. Janzen, Lisa M. Johnson, Anne G. Lindgren, Anh Thai-Quynh Nguyen8, Ekaterina Tiourin, Angela B. Soriaga, Jing Lu, Lin Jiang9, Kym F. Faull, Matteo Pellegrini, Sanaz Memarzadeh, David S. Eisenberg

    http://www.cell.com/cancer-cell/fulltext/S1535-6108(15)00466-3

    AND

    Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

    Shaokun Shu, Charles Y. Lin, Housheng Hansen He, Robert M. Witwicki, Doris P. Tabassum, Justin M. Roberts, Michalina Janiszewska, Sung Jin Huh, Yi Liang, Jeremy Ryan, Ernest Doherty, Hisham Mohammed, Hao Guo, Daniel G. Stover, Muhammad B. Ekram, Guillermo Peluffo, Jonathan Brown, Clive D’Santos, Ian E. Krop, Deborah Dillon, Michael McKeown, Christopher Ott, Jun Qi, Min Ni, Prakash K. Rao

    http://www.nature.com/nature/journal/v529/n7586/full/nature16508.html

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  3. Review
    Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition
    Spencer C. Wei, Jing Yang

    Click to access S0962-8924(15)00185-3.pdf

    AND

    PERSPECTIVES
    TIMELINE
    Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
    Alex R. D. Delbridge, Stephanie Grabow, Andreas Strasser & David L. Vaux
    p99 | doi:10.1038/nrc.2015.17
    http://www.nature.com/nrc/journal/v16/n2/full/nrc.2015.17.html

    ______________________________________________
    AND short mention to…
    Technology
    Real-Time Three-Dimensional Cell Segmentation in Large-Scale Microscopy Data of Developing Embryos
    Johannes Stegmaier, Fernando Amat, William C. Lemon, Katie McDole, Yinan Wan, George Teodoro, Ralf Mikut, Philipp J. Keller

    http://www.cell.com/developmental-cell/fulltext/S1534-5807(15)00837-0

    AND just to share the news in case you didn’t spot them…
    uk-scientists-gain-licence-to-edit-genes-in-human-embryos
    http://www.nature.com/news/uk-scientists-gain-licence-to-edit-genes-in-human-embryos-1.19270?WT.mc_id=FBK_NA_1601_NEWSUKSCIEDITGENOMES_PORTFOLIO

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  4. A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
    John Y. Licorrespondenceemail, Samuel R. Perry, Vanessa Muniz-Medina, Xinzhong Wang6, Leslie K. Wetzel, Marlon C. Rebelatto, Mary Jane Masson Hinrichs, Binyam Z. Bezabeh, Ryan L. Fleming, Nazzareno Dimasi, Hui Feng7, Dorin Toader, Andy Q. Yuan, Lan Xu, Jia Lin, Changshou Gao, Herren Wu, Rakesh Dixit, Jane K. Osbourn, Steven R. Coats
    6Present address: Merck Research Laboratories, Boston, MA 02115, USA
    7Present address: Topalliance Bioscience Inc., Menlo Park, CA 94025, USA

    http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00472-9

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