Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
Julia Tchou, Yangbing Zhao, Bruce L. Levine, Paul J Zhang, Megan M. Davis, Jan Joseph Melenhorst, Irina Kulikovskaya, Andrea L Brennan, Xiaojun Liu, Simon F. Lacey, Avery D. Posey Jr., Austin D. Williams, Alycia So, Jose R. Conejo-Garcia, Gabriela Plesa, Regina M. Young, Shannon McGettigan, Jean Campbell, Robert H. Pierce, Jennifer M. Matro, Angela M. DeMichele, Amy S. Clark, Laurence J. Cooper, Lynn M. Schuchter, Robert H. Vonderheide and Carl H. June
Chia-Wei Li13, Seung-Oe Lim13, Ezra M. Chung, Yong-Soo Kim, Andrew H. Park, Jun Yao, Jong-Ho Cha, Weiya Xia, Li-Chuan Chan, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Chao-Kai Chou, Yen-Liang Liu, Hsin-Chih Yeh, Evan P. Perillo, Andrew K. Dunn, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Tzu-Hsuan Huang, Aysegul A. Sahin, Gabriel N. Hortobagyi, Stephen S. Yoo, Mien-Chie Hung https://www.nature.com/articles/ncomms12632
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling
Kai Kessenbrock, Prestina Smith, Sander Christiaan Steenbeek, Nicholas Pervolarakis, Raj Kumar, Yasuhiro Minami, Andrei Goga, Lindsay Hinck, and Zena Werb
PNAS March 21, 2017. 114 (12) 3121-3126; published ahead of print March 7, 2017. https://doi.org/10.1073/pnas.1701464114 http://www.pnas.org/content/114/12/3121
The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy
Jordan A. Krall1, Ferenc Reinhardt1, Oblaise A. Mercury1, Diwakar R. Pattabiraman1, Mary W. Brooks1, Michael Dougan1,2, Arthur W. Lambert1, Brian Bierie1, Hidde L. Ploegh1,3,*, Stephanie K. Dougan1,4 and Robert A. Weinberg1,3,5,†
Elife. 2018 Mar 21;7. pii: e26161. doi: 10.7554/eLife.26161.
Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling.
Ricca BL#1, Venugopalan G#1, Furuta S2, Tanner K2,3, Orellana WA2,3, Reber CD1, Brownfield DG1,2, Bissell MJ2, Fletcher DA1,2.
Author information
Abstract
Non-malignant breast epithelial cells cultured in three-dimensional laminin-rich extracellular matrix (lrECM) form well organized, growth-arrested acini, whereas malignant cells form continuously growing disorganized structures. While the mechanical properties of the microenvironment have been shown to contribute to formation of tissue-specific architecture, how transient external force influences this behavior remains largely unexplored. Here, we show that brief transient compression applied to single malignant breast cells in lrECM stimulated them to form acinar-like structures, a phenomenon we term ‘mechanical reversion.’ This is analogous to previously described phenotypic ‘reversion’ using biochemical inhibitors of oncogenic pathways. Compression stimulated nitric oxide production by malignant cells. Inhibition of nitric oxide production blocked mechanical reversion. Compression also restored coherent rotation in malignant cells, a behavior that is essential for acinus formation. We propose that external forces applied to single malignant cells restore cell-lrECM engagement and signaling lost in malignancy, allowing them to reestablish normal-like tissue architecture.
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Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
Julia Tchou, Yangbing Zhao, Bruce L. Levine, Paul J Zhang, Megan M. Davis, Jan Joseph Melenhorst, Irina Kulikovskaya, Andrea L Brennan, Xiaojun Liu, Simon F. Lacey, Avery D. Posey Jr., Austin D. Williams, Alycia So, Jose R. Conejo-Garcia, Gabriela Plesa, Regina M. Young, Shannon McGettigan, Jean Campbell, Robert H. Pierce, Jennifer M. Matro, Angela M. DeMichele, Amy S. Clark, Laurence J. Cooper, Lynn M. Schuchter, Robert H. Vonderheide and Carl H. June
http://cancerimmunolres.aacrjournals.org/content/5/12/1152
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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
Teemu P Miettinen, Julien Peltier, Anetta Härtlova, Marek Gierliński, Valerie M Jansen, View ORCID ProfileMatthias Trost, Mikael Björklund
http://emboj.embopress.org/content/37/10/e98359
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Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Chia-Wei Li, Seung-Oe Lim, Weiya Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, Kay-Hooi Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Qingqing Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, Aysegul A. Sahin, James P. Allison, Dihua Yu, Gabriel N. Hortobagyi & Mien-Chie Hung
https://www.nature.com/articles/ncomms12632
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
Chia-Wei Li13, Seung-Oe Lim13, Ezra M. Chung, Yong-Soo Kim, Andrew H. Park, Jun Yao, Jong-Ho Cha, Weiya Xia, Li-Chuan Chan, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Chao-Kai Chou, Yen-Liang Liu, Hsin-Chih Yeh, Evan P. Perillo, Andrew K. Dunn, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Tzu-Hsuan Huang, Aysegul A. Sahin, Gabriel N. Hortobagyi, Stephen S. Yoo, Mien-Chie Hung
https://www.nature.com/articles/ncomms12632
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Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling
Kai Kessenbrock, Prestina Smith, Sander Christiaan Steenbeek, Nicholas Pervolarakis, Raj Kumar, Yasuhiro Minami, Andrei Goga, Lindsay Hinck, and Zena Werb
PNAS March 21, 2017. 114 (12) 3121-3126; published ahead of print March 7, 2017. https://doi.org/10.1073/pnas.1701464114
http://www.pnas.org/content/114/12/3121
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The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy
Jordan A. Krall1, Ferenc Reinhardt1, Oblaise A. Mercury1, Diwakar R. Pattabiraman1, Mary W. Brooks1, Michael Dougan1,2, Arthur W. Lambert1, Brian Bierie1, Hidde L. Ploegh1,3,*, Stephanie K. Dougan1,4 and Robert A. Weinberg1,3,5,†
http://stm.sciencemag.org.libproxy.helsinki.fi/content/10/436/eaan3464
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https://elifesciences.org/articles/26161/figures#fig1s1
Elife. 2018 Mar 21;7. pii: e26161. doi: 10.7554/eLife.26161.
Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling.
Ricca BL#1, Venugopalan G#1, Furuta S2, Tanner K2,3, Orellana WA2,3, Reber CD1, Brownfield DG1,2, Bissell MJ2, Fletcher DA1,2.
Author information
Abstract
Non-malignant breast epithelial cells cultured in three-dimensional laminin-rich extracellular matrix (lrECM) form well organized, growth-arrested acini, whereas malignant cells form continuously growing disorganized structures. While the mechanical properties of the microenvironment have been shown to contribute to formation of tissue-specific architecture, how transient external force influences this behavior remains largely unexplored. Here, we show that brief transient compression applied to single malignant breast cells in lrECM stimulated them to form acinar-like structures, a phenomenon we term ‘mechanical reversion.’ This is analogous to previously described phenotypic ‘reversion’ using biochemical inhibitors of oncogenic pathways. Compression stimulated nitric oxide production by malignant cells. Inhibition of nitric oxide production blocked mechanical reversion. Compression also restored coherent rotation in malignant cells, a behavior that is essential for acinus formation. We propose that external forces applied to single malignant cells restore cell-lrECM engagement and signaling lost in malignancy, allowing them to reestablish normal-like tissue architecture.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
https://www-nature-com.libproxy.helsinki.fi/articles/s41556-018-0083-6
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