07.3.2018 General

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9 thoughts on “07.3.2018 General”

  1. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

    Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano & Atsushi Shibata

    https://www.nature.com/articles/s41467-017-01883-9

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  2. Mapping the Mouse Cell Atlas by Microwell-Seq

    Xiaoping Han, Renying Wang, Yincong Zhou, Lijiang Fei, Huiyu Sun, Shujing Lai, Assieh Saadatpour, Zimin Zhou, Haide Chen, Fang Ye, Daosheng Huang, Yang Xu, Wentao Huang, Mengmeng Jiang, Xinyi Jiang, Jie Mao, Yao Chen, Chenyu Lu, Jin Xie, Qun Fang, Yibin Wang, Rui Yue, Tiefeng Li, He Huang, Stuart H. Orkin, Guo-Cheng Yuan, Ming Chen, Guoji Guo

    http://www.cell.com/cell/abstract/S0092-8674(18)30116-8

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  3. https://www.nature.com/articles/s41467-017-01076-4.pdf

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    Nat Commun. 2017 Oct 23;8(1):1096. doi: 10.1038/s41467-017-01076-4.
    Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.
    Semrau S1,2,3, Goldmann JE4, Soumillon M5,6, Mikkelsen TS5,6, Jaenisch R4,7, van Oudenaarden A8.
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    Abstract

    Gene expression heterogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-characterized. In contrast, exit from pluripotency and lineage commitment have not been studied systematically at the single-cell level. Here we measure the gene expression dynamics of retinoic acid driven mESC differentiation from pluripotency to lineage commitment, using an unbiased single-cell transcriptomics approach. We find that the exit from pluripotency marks the start of a lineage transition as well as a transient phase of increased susceptibility to lineage specifying signals. Our study reveals several transcriptional signatures of this phase, including a sharp increase of gene expression variability and sequential expression of two classes of transcriptional regulators. In summary, we provide a comprehensive analysis of the exit from pluripotency and lineage commitment at the single cell level, a potential stepping stone to improved lineage manipulation through timing of differentiation cues.

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  4. Distinct histone modifications denote early stress-induced drug tolerance in cancer

    Abdullah Al Emran1,*, Diego M. Marzese2,*, Dinoop Ravindran Menon1, Mitchell S. Stark1, Joachim Torrano1, Heinz Hammerlindl1, Gao Zhang4, Patricia Brafford4, Matthew P. Salomon2, Nellie Nelson3, Sabrina Hammerlindl1, Deepesh Gupta1, Gordon B. Mills5, Yiling Lu5, Richard A. Sturm1, Keith Flaherty6, Dave S. B. Hoon2, Brian Gabrielli7, Meenhard Herlyn4 and Helmut Schaider1

    http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=23654&path%5B%5D=74469

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  5. ARTICLESwitch to Standard View
    The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
    Daniel Zingg3, Natalia Arenas-Ramirez3, Dilara Sahin, Rodney A. Rosalia, Ana T. Antunes, Jessica Haeusel, Lukas Sommer4,’Correspondence information about the author Lukas SommerEmail the author Lukas Sommer, Onur Boyman4,5,’Correspondence information about the author Onur BoymanEmail the author Onur Boyman
    3These authors contributed equally
    4Senior author
    5Lead Contact
    Open Access
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    DOI: https://doi.org/10.1016/j.celrep.2017.07.007 |
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