7 thoughts on “JC 17.2.2016: General”

  1. TOPI

    NATURE COMMUNICATIONS

    KRAS insertion mutations are oncogenic and exhibit distinct functional properties

    Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Chao Zhang, Heidi Carias, David Dickens, Mignon Loh, Kevin Shannon & Ari J. Firestone

    Click to access ncomms10647.pdf

    Like

  2. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

    Roberta Scognamiglio, Nina Cabezas-Wallscheid, Marc Christian Thier, Sandro Altamura, Alejandro Reyes, Áine M. Prendergast, Daniel Baumgärtner, Larissa S. Carnevalli, Ann Atzberger, Simon Haas, Lisa von Paleske, Thorsten Boroviak, Philipp Wörsdörfer, Marieke A.G. Essers, Ulrich Kloz, Robert N. Eisenman, Frank Edenhofer, Paul Bertone, Wolfgang Huber, Franciscus van der Hoeven, Austin Smith, Andreas Trumpp

    http://www.cell.com/cell/abstract/S0092-8674(15)01697-9

    Highlights
    •Myc-depleted ESCs exhibit reversible biosynthetic dormancy and proliferation arrest
    •Myc expression is strongly reduced in hormonally induced diapause embryos
    •Myc mutant ESCs and diapause embryos have similar expression signatures
    •Myc depletion induces a reversible, pluripotent diapause-like state in blastocysts

    Like

  3. Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

    Cancer Cell

    Jungoh Ham11, Carlotta Costa11, Renata Sano, Timothy L. Lochmann, Erin M. Sennott, Neha U. Patel, Anahita Dastur, Maria Gomez-Caraballo, Kateryna Krytska, Aaron N. Hata, Konstantinos V. Floros, Mark T. Hughes, Charles T. Jakubik, Daniel A.R. Heisey, Justin T. Ferrell, Molly L. Bristol, Ryan J. March, Craig Yates, Mark A. Hicks, Wataru Nakajima, Madhu Gowda, Brad E. Windle, Mikhail G. Dozmorov, Mathew J. Garnett, Ultan McDermott, Hisashi Harada, Shirley M. Taylor, Iain M. Morgan, Cyril H. Benes, Jeffrey A. Engelman, Yael P. Mossé, Anthony C. Faber

    http://www.cell.com/cancer-cell/abstract/S1535-6108(16)00031-3

    Like

  4. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

    Simona Frateschi, Eric Camerer, Giovanna Crisante, Sarah Rieser, Mathieu Membrez, Roch-Philippe Charles, Friedrich Beermann, Jean-Christophe Stehle, Bernadette Breiden, Konrad Sandhoff, Samuel Rotman, Marek Haftek, Anne Wilson, Stephan Ryser, Martin Steinhoff, Shaun R. Coughlin & Edith Hummler
    AffiliationsContributionsCorresponding author
    Nature Communications 2, Article number: 161 doi:10.1038/ncomms1162
    Received 17 May 2010 Accepted 08 December 2010 Published 18 January 2011
    Article tools
    http://www.nature.com/ncomms/journal/v2/n1/full/ncomms1162.html

    Like

  5. 10.1073/pnas.1508541113
    Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s